A spill doesn't necessarily mean keyboard death, but resuscitation can take some elbow grease. Unplug the keyboard (or for wireless models, remove the batteries), break out the screwdriver and take that baby apart. It can take some time; my Logitech has at least two dozen screws holding it together. Lay out the pieces one by one and wipe them down with a slightly-damp cloth to get off any sticky residue. Use a dry paper towel to mop up drops. If you've got compressed air handy, this is a great time to blow out any dust, too.

When all the parts are dry as a bone, carefully reassemble them. All's well for me now; I'm typing this very post on the keyboard. Here are some photos of my keyboard's innards from this morning's clean-up.